The invention discloses a nailing machine for setting up and fixing fireproof waterproof materials of a mobile house, comprising a run debugger, an energy storage pipe box and a rotational power rod. The rotational power rod is disposed in the center of the machine and is protectively mounted through the outside of a protective chamber; the rotational power rod may adjust its length as material strength requires; a nail bending adjusting rack is disposed above the tail end of the protective chamber; the tail end of the rotational power rod is fixedly connected with a nail driver and is fixed through a high-speed extrusion sealing support ring; a nail path corrector is mounted outside the nail driver; the front side of the protective chamber is connected with a conical pressure-adjusting high-speed thruster; the front side of the conical pressure-adjusting high-speed thruster is connected with the energy storage pipe box. The nailing machine is reasonable in design, low in cost, high in positioning precision and nailing efficiency and convenient to use, provides maximized economic benefit and has a promising application prospect in the industry of setup and fixation of a mobile house.