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发明授权
CN105859805B 核桃青皮中一种新的酚苷化合物的制备方法和用途 失效 - 权利终止

核桃青皮中一种新的酚苷化合物的制备方法和用途
摘要：
本发明属于医药技术领域，涉及从核桃楸（Juglans mandshurica Maxim）的青果皮中提取分离得到具有体外抗肿瘤活性的一种新的酚苷化合物及其制备方法。本发明方法以核桃青皮为原料，经过醇提，大孔树脂富集纯化，硅胶柱层析和凝胶柱层析，再结合制备HPLC纯化得到了一种新的酚苷化合物4‑羟基苯丙酮‑4‑O‑β‑D‑吡喃葡萄糖基(1→6)‑β‑D‑吡喃葡萄糖苷[4‑hydroxypropiophenone‑4‑O‑β‑D‑glucopyranosyl(1→6)‑β‑D‑glucopyranoside]。本发明所涉及的原料容易大量获取，且该新化合物经实验证实对胃癌、肝癌和乳腺癌等细胞均具有较好的抑制作用。
摘要（英）：

The invention belongs to the technical field of medicines, and relates to a novel phenolic glycoside compound and a preparation method thereof. The novel novel phenolic glycoside compound is extracted and separated from green peel of Juglans mandshurica Maxim and has antitumor activity in vitro. The preparation method includes subjecting green peel of Juglans mandshurica Maxim to alcohol extraction, enrichment and purification by macroporous resin, chromatography by silicagel columns and chromatography by gel columns sequentially, and then preparing HPLC and purifying the same to obtain the novel phenolic glycoside compound: 4 -hydroxypropiophenone-4-O-Beta-D-glucopyranosyl (1->6) -Beta-D-glucopyranoside. The raw material for preparing the compound is wide in source and easy to obtain; the novel compound has effective inhabitation effect to gastric carcinoma cells, liver cancer cells, breast cancer cells and the like as proved by tests.

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