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发明授权
CN105866426B 用于检测补体结合性抗体的方法和组合物 有权

用于检测补体结合性抗体的方法和组合物
摘要：
本发明提供了用于使用补体因子C1q灵敏且特异性地检测生物样品中的补体结合性抗体的方法，所述补体因子C1q包括在生物样品中存在的自体补体因子C1q和结合自体补体因子C1q的可检测地标记的抗体、外源性人补体因子C1q和结合外源性人补体因子C1q的可检测地标记的抗体、可检测地标记的外源性人补体因子C1q、或自体补体因子C1q和外源性人补体因子C1q的组合。本发明也表征了用于本发明方法中的试剂盒、系统和装置。
摘要（英）：

The invention provides methods for sensitive and specific detection of complement fixing antibodies in a biological sample using complement factor C1q, including autologous complement factor C1q present in the biological sample and a detectably labeled antibody that binds the autologous complement factor C1q, exogenous human complement factor C1q and a detectably labeled antibody that binds the exogenous human complement factor C1q, detectably labeled exogenous human complement factor C1q, or a combination of autologous complement factor C1q and exogenous human complement factor C1q. The invention also features kits, systems, and devices for use in the methods of the invention.

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