The present invention relates to a route planning method oriented to goods delivery. A method of grouping firstly and then arranging a route is adopted, and a large-scale logistics delivery vehicle path problem is divided into multiple small-scale logistics delivery vehicle path problems, so that a calculation amount can be greatly reduced, and a solution speed is improved. Moreover, for a constraint to a load weight of a freight vehicle, relatively high uniformity of the number of delivery points in each delivery region obtained by division is ensured by adding a limitation to a capacity constraint for each cluster set in a clustering method, so that a total weight of goods in the delivery region obtained by division will not exceed a maximum load weight of the freight vehicle, and region division becomes more reasonable; and furthermore, by integrally considering an optimization principle of a freight vehicle route and a regional principle of a delivery point geographical location, a same freight vehicle is arranged for the delivery points of which the geographical locations are close to each other, and therefore, the delivery efficiency is improved.