The invention discloses an intelligent operation and maintenance and overhaul system applied to integrated operation and maintenance and overhaul of power transformation equipment. The intelligent operation and maintenance and overhaul system comprises an intelligent operation and maintenance and overhaul box, a detection instrument, mobile control equipment and a server. The data input end of the intelligent operation and maintenance and overhaul box is connected with the data output end of the detection instrument, the mobile control equipment is in data communication with the intelligent operation and maintenance and overhaul box through the 802.11 protocol, and the server is in real-time data transmission with the intelligent operation and maintenance and overhaul box through a 3G/4G network. By establishing an intelligent transit body of an intercommunication system of a field side and a center side for operation and maintenance and overhaul of the power transformation equipment, normalization of field data and normalization of work can be achieved through the mobile internet, support and guidance can be provided for normalization of the field work of operation and maintenance and overhaul of the power transformation equipment, and a certain data analysis function is achieved.