利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN105878220A 倍半萜类化合物在制备防治高血脂药物中的应用 失效 - 权利终止 转让

倍半萜类化合物在制备防治高血脂药物中的应用
摘要：
本发明公开了倍半萜类化合物在制备防治高血脂药物中的应用，所述倍半萜类化合物结构式如式(I)或式(II)所示：其中，R1为氢、羟基、氨基、硝基、氰基、C1?8烷基、取代的C1?8烷基、C5?8环烷基、取代的C5?8环烷基、C5?6芳香基、取代的C5?6芳香基、C9?18稠环芳香基、取代的C9?18稠环芳香基、C5?6杂环基、取代的C5?6杂环基、C5?6芳杂环基或取代的C5?6芳杂环基；所述R2的定义和R1的相同。本发明所述倍半萜类化合物对甘油三酯的形成具有抑制效果，且对宿主毒性小，安全性高，可应用于制备防治高脂血症的药物。
摘要（英）：

The invention discloses application of a sesquiterpenic compound in preparation of pharmaceuticals for preventing and treating hyperlipidemia. The sesquiterpenic compound has a structural formula shown as in formula (I) or (II), wherein R1 is hydrogen, hydroxyl groups, amino groups, nitro groups, C1-8 alkyls, substituted C1-8 alkyls, C5-8 naphthenic groups, substituted C5-8 naphthenic groups, C5-6 aryls, substituted C5-6 aryls, C9-18 condensed aryls, substituted C9-18 condensed aryls, C5-6 heterocyclic groups, substituted C5-6 heterocyclic groups, C5-6 heterocyclic aryls, or substituted C5-6 heterocyclic aryls; R2 is as defined as R1. The sesquiterpenic compound of the invention can inhibit triglyceride, has low toxicity to a host, is high in safety and is applicable to the preparation of pharmaceuticals for preventing and treating hyperlipidemia.

公开/授权文献
0/0