The invention relates to an anti-hydrogen-induced-cracking pressure vessel steel plate containing, chemical composition of the steel plate according to the weight percentage: 0.16-0.20% of C, 0.15-0.40% of Si, 1.05-1.20% of Mn, less than or equal to 0.008% of P, less than or equal to 0.002% of S, less than or equal to 0.01% of Nb, less than or equal to 0.01% of V, less than or equal to 0.01% of Ti, less than or equal to 0.0005% of B, and the balance being Fe and inevitable impurity elements; carbon equivalent Ceq is less than or equal to 0.42%, and the computational formula for the carbon equivalent is Ceq=C+Mn/6+(Cr+Mo+V)/5+(Ni+Cu)/15. The steel plate has high strength and low temperature impact toughness, low hardness and excellent anti-HIC performance. The steel plate has fine grains and low non-metallic inclusion content, and does not have any obvious banded structure. After long-time high-temperature simulated post-welding heat treatment, the strength and the low temperature impact toughness of the steel plate are not reduced obviously.