The invention provides a method applicable to repeatedly transforming a stratum nearby a shaft of a low-pressure gas field old well to complete permanent blocking. The method is characterized by mixing micro-grade resin with cement before repeated transformation, pumping a mixture of the micro-grade resin and the cement into the stratum nearby the shaft, and permanently blocking holes and cracks in a low-pressure voidage zone around the old well. According to the method applicable to repeatedly transforming the stratum nearby the shaft of the low-pressure gas field old well to complete the permanent blocking, provided by the invention, the micro-grade resin and the cement are mixed, and the mixture of the micro-grade resin, and the cement is pumped into the stratum around the shaft before refracturing; since the particle diameter of ultrafine plugging agent particles is smaller and the ultrafine plugging agent particles have good fluidity and good penetrability, the ultrafine plugging agent particles can permeate into the holes of a reservoir stratum so as to permanently block the holes and the cracks in the low-pressure voidage zone around the old well, leakage of fracturing liquid to the stratum is slowed down, and the fracture making efficiency of the fracturing liquid is increased.