The invention discloses a power distribution network operation-maintenance cockpit based on operation and distribution data and application thereof. The operation-maintenance cockpit comprises a quasi real-time data center and an application center, the quasi real-time data center is used for being connected with a production system, a dispatching system and a marketing system of an electric power company, obtaining production, dispatching and marketing operation data, and storing, centralizing, integrating, sharing and analyzing the operation data. The application center is connected with the quasi real-time data center through a uniform access interface and is used for calling a corresponding calculation module to process the operation data to obtain the operation state of a power distribution network or an assessment result of a single index according to a functional module and corresponding parameters selected by a user on a human-computer interface, and displaying the operation state of the power distribution network or the assessment result of the single index obtained through processing on the human-computer interface. Centralized operation monitoring, analyzing, controlling and managing are carried out on the power distribution network within a domain by means of the power distribution network operation-maintenance cockpit, and the cockpit is suitable for on-line risk assessment and early warning and capable of effectively promoting the capacity for operating the complex power distribution network of the user.