The invention discloses gradually-changed continuous irregular color line jean cloth. The gradually-changed continuous irregular color line jean cloth comprises warp yarns and weft yarns, wherein the warp yarns and the weft yarns are alternately arranged; yarns in the warp yarns are color lines which are spun by more than two alternate colors and which have consistent or inconsistent thicknesses; indigo blue dyeing layers are arranged on the color lines. The invention further provides a manufacturing method of the gradually-changed continuous irregular color line jean cloth, and the manufacturing method comprises the following steps: S1, providing yarns: alternately feeding more than two original raw cotton materials with different colors so as to spin the color lines; S2, forming the warp yarns; S3, making the warp yarns be indigo blue; S4, carrying out drafting and the weaving the warp yarns with the weft yarns. The gradually-changed continuous irregular color line jean cloth and the manufacturing method have the advantage of providing a new jean cloth manufacturing method.