The invention provides a high-power water-cooling electric pile structure. The high-power water-cooling electric pile structure comprises multiple power generation units and tail plates on the upper and lower sides, wherein a negative electrode inlet, a negative electrode outlet, a positive electrode inlet, a positive electrode outlet, a cooling inlet and a cooling outlet are formed in one tail plate; each power generation unit comprises dual polar plates; valve structures are arranged on the left and right sides of the electric pile; the valve structures are integrated with gas channels of the negative electrode inlet and the negative electrode outlet of the electric pile; and a negative electrode inlet valve body and a negative electrode outlet valve body are formed on the left and right sides of the electric pile respectively. The high-power water-cooling electric pile structure enables the voltage drop of the negative electrode loop to be lowered and the gas distribution to be more uniform by enlarging the negative electrode inlet area and lowering the wind resistance.