The invention discloses an efficient plastic screw cleaning agent, a production method and a use method. The efficient plastic screw cleaning agent is prepared from, by mass, 100 parts of thermoplastic elastomer, 40-80 parts of short glass fibers, 4-8 parts of a surfactant, namely, sodium alpha-olefin sulfonate, 2-5 parts of an alkaline agent, namely, sodium silicate and 3-5 parts of a lubricant. The efficient plastic screw cleaning agent has the advantages of being high in safety, good in cleaning effect, low in cost and the like. The production method of the efficient plastic screw cleaning agent includes the steps that the raw materials are put into a high-speed mixer to form mixed raw materials; then, the mixed raw materials are extruded and pelletized. The use method of the efficient plastic screw cleaning agent includes the steps that the efficient plastic screw cleaning agent is put into polymer molding equipment provided with a screw, and then the efficient plastic screw cleaning agent is extruded with polymer raw materials to be formed till cleaning is completed.