The invention relates to a traditional Chinese medicine preparation for treating neurasthenia. The traditional Chinese medicine preparation is prepared from Chinese thorowax roots, raw dragon's bones, raw oyster shells, radix scutellariae, cassia twigs, radix et rhizoma rhei, radix asparagi, poria with hostwood, Chinese magnoliavine fruit, root-bark of Chinese wolfberry, fructus forsythiae, exocarpium citri rubrum, semen plantaginis, ginseng, polygala roots, licorice roots, ramulus uncariae cum uncis, rhizoma acori graminei, calculus bovis and cornu saigae tataricae. The traditional Chinese medicine preparation is prepared through multiple times of clinical compatibility of all the traditional Chinese medicines, after the traditional Chinese medicine preparation is taken, the medicines reach the heart and the kidney through the stomach and the liver of a human body, the effects of tranquilizing and allaying excitement, strengthening heart-yang, benefiting heart qi, tonifying the spleen, benefiting qi, replenishing the blood, nourishing yin and benefiting the kidney are achieved, and both symptoms and root causes are treated. It is clinically proved that the traditional Chinese medicine preparation is good in absorption effect, free of adverse, toxic and side effects and capable of balancing brain dysfunction, not only can improve the internal environment of the human body, but also can improve the whole body health condition to enable a patient to be full of energy and has a significant curative effect on various symptoms caused by the neurasthenia.