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发明公开
CN105944146A 生物医用多孔镁骨组织工程支架制备方法 无效 - 驳回

生物医用多孔镁骨组织工程支架制备方法
摘要：
本发明公开一种生物医用多孔镁骨组织工程支架制备方法，包括：(1)用逆向工程及CAD技术以得到初始CAD模型；(2)用CAE分析软件对初始CAD模型优化；(3)对初始CAD模型修正以得到修正CAD模型；(4)用分层软件对修正CAD模型切片分层以得到轮廓数据；(5)将镁合金粉末与碳酸钙粉末混合以得到混合粉末；(6)激光快速成型机对混合粉末逐层熔化以得到骨组织工程支架；(7)对所有的骨组织工程支架降解速度实验，以筛出骨组织工程支架；激光逐层参数：扫描速度3‑4米每秒；功率30‑40瓦；扫描间距1‑1.5毫米；光斑直径0.3‑0.4毫米，以制备出梯度多孔结构、生物相容性好及降解速度可控的骨组织工程支架。
摘要（英）：

The invention discloses a preparation method of a biomedical porous magnesium bone tissue engineering scaffold. The method includes: (1) using reverse engineering and CAD technology to obtain an initial CAD model; (2) using CAE analysis software to optimize the initial CAD model; (3) amending the initial CAD model to obtain the amended CAD model; (4) slicing and layering the amended CAD model by using layering software to obtain contour data; (5) mixing the magnesium alloy powder and calcium carbonate powder to obtain a mixed powder; (6) fusing the mixed powder layer by layer with a laser rapid forming machine to obtain the bone tissue engineering scaffold; and (7) performing degradation velocity experiment for all the bone tissue engineering scaffolds to select the bone tissue engineering scaffold. The laser parameters layer by layer includes: scanning speed of 3-4m/s; power of 30-40w; scanning interval of 1-1.5mm; and spot diameter of 0.3-0.4mm. The prepared bone tissue engineering scaffold has gradient porous structure, good biocompatibility and controllable degradation velocity.

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