The invention relates to an equipment positioning device. Guide pillars are arranged below equipment. The equipment positioning device further comprises a positioning device which can position the equipment; the positioning device comprises a fixed plate and side guiding plates, wherein one side guiding plate is mounted at the front side of the upper portion of the fixed plate, and the other side guiding plate is mounted at the rear side of the upper portion of the fixed plate; the left end of the fixed plate is provided with an inclined plane, and a positioning baffle capable of blocking the equipment is mounted on the upper portion of the right end of the fixed plate; and a clamping mechanism component which can lock the guide pillars below the equipment is mounted at the position, located on the right of the positioning baffle, of the upper portion of the right end of the fixed plate. The equipment is pushed to the fixed plate from one end of the fixed plate, and it is continued to push the equipment under the guiding action of the side guiding plates till the equipment is attached to the positioning baffle; and the guide pillars below the equipment enter guiding grooves in the clamping mechanism component. An air cylinder is contracted and drives a front clamping block and a rear clamping block to move, and the guide pillars below the equipment are locked, so that it is guaranteed that the equipment does not shake and is precise in position. By means of the equipment positioning device, the equipment can be fixed to the sole position on the positioning device stably and precisely, and uniqueness and definiteness of the position are guaranteed.