The invention provides an automatic cleaning system for a full-automatic intelligent spinning machine nozzle. The automatic cleaning system comprises an air supply system and an automatic control system, wherein the automatic control system is connected with the air supply system and controls the same to supply air to a cleaning nozzle and an N2 sprayer in the air supply system according to the time sequence requirement so as to complete the cleaning of the whole cleaning nozzle and the yarn pre-twisting performed by the whole N2 sprayer. The automatic cleaning system has the advantages that the pressure of the air conveyed to the cleaning nozzle can be adjusted according to different fiber lengths and varieties and process requirements, a factory air source is pressurized and stabilized through a pressurizing pump, the air pressure range of the cleaning nozzle is adjusted through a pressure adjusting valve, high-precision control is achieved, the air pressure control of the cleaning nozzle is high in precision and good in consistency, the adjustable range of the air pressure of the cleaning nozzle is wide, a control module ECU is used to perform time sequence control on a nozzle control electromagnetic valve, high control precision is achieved, time sequence control precision is +/-1ms, time sequence intersection of two air paths is avoided, and yarn spraying yield is increased effectively.