The invention discloses a rail biting prevention device for a wheel system with a flange. The rail biting prevention device comprises frames, pressure plates, transmission plates, transmission rods, rotary frames, reset plates, a connecting plate, connecting rods, rotary rods, auxiliary connecting rods and drive rings, wherein a wheel groove used for the flange of the wheel system to be embedded into is formed in one side of each frame; the two side walls of each wheel groove are the inner side wall and the outer side wall respectively; each pressure plate is arranged on the inner side of the corresponding inner side wall; each transmission plate is arranged on the outer side of the corresponding inner side wall; each pressure plate is connected with the corresponding transmission plate to carry out linkage; one end of each transmission rod is hinged to the corresponding transmission plate; each rotary frame is in an Y shape; the first end of each rotary frame is hinged to the other end of the corresponding transmission rod; the second end of each rotary frame is rotationally arranged on the outer side of the corresponding outer side wall; each reset plate is arranged on the inner side of the corresponding outer side wall; one end of the connecting plate is arranged on the outer side of the corresponding outer side wall; each connecting rod is arranged on the outer side of the connecting plate; one end of each connecting rod is connected with the third end of the corresponding rotary frame; each rotary rod is arranged on the outer side of the connecting plate; one end of each rotary rod is hinged to the other end of the corresponding connecting rod; each auxiliary connecting rod is arranged on the outer side of the connecting plate; one end of each auxiliary connecting rod is hinged to the connecting plate; each drive ring is embedded in the corresponding outer side wall; one end of each drive ring is hinged to the other end of the corresponding auxiliary connecting rod; the other end of each drive ring is abutted to the corresponding reset plate; and a plurality of parts outsides the connecting plate are arranged with a symmetric structure. The rail biting prevention device can prevent wheels from deflecting.