The invention discloses a simplified over-current detection circuit for a high-side power tube. The simplified over-current detection circuit comprises a high-side power tube, a load, a transistor, a voltage-dividing resistor, a switching tube, a first tail current source and a second tail current source, a logic circuit and a delay circuit. The logic circuit is used for introducing an enabling signal. The high-side power tube is an NMOS tube; the triode is a PNP tube or an NPN tube; and the switching tube is a PMOS tube. The triode is configured to have a translation voltage; the logic circuit is an AND gate. When the switching tube is in conduction, a drain terminal high level is converted into a low level that is provided for the logic circuit. The load is an inductive load, a resistive load or a short-circuit grounding unit. The resistance proportion of the first resistor to the second resistor can be adjusted. The enabling signal and a drive signal of the high-side power tube are synchronous. According to the invention, detection of the current detection circuit becomes direct; no auxiliary device is needed; and the detection precision is high. Under the circumstance that the current detection precision is improved, the circuit structure become simple; easy adjusting is realized; the occupied chip area is small; the domain layout becomes convenient; the chip cost is saved; and easy transplanting is realized.