The invention discloses a personification strategy based rectangular layout method with mass balance constraint. The method utilizes quasi-physical idea to convert a rectangular layout problem with mass balance performance constraint into an unconstrained optimization problem, takes attract disc filling algorithm (BF) as the basis, uses a personification local movement strategy to conduct local search, and at the same time employs a heuristic selection strategy and a personification corner-occupying placement strategy in terms of layout updating, thus obtaining a new layout algorithm. Through experimental verification, the method provided by the invention combines improved BF algorithm of global search with the personification local movement strategy, optimizes the overall efficiency of the algorithm, and effectively improves the area utilization ratio of the layout.