The invention discloses a perforating machine for a manifold. The perforating machine comprises a base, wherein a first support bar and a second support bar which are mutually symmetrical are fixedly connected with the top of the base; one side surface of the first support bar is fixedly connected with a support plate; a motor is arranged at the top of the support plate; the output end of the motor is fixedly connected with an eccentric wheel; a rotary disc is arranged on one side surface of the second support bar; a bearing is arranged between the first support bar and the second support bar; the interior of the bearing is fixedly connected with a connecting bar; one end of the connecting bar extends to one side surface of the bearing and is fixedly connected with the rotary disc; and the other end of the connecting bar extends to the other side surface of the bearing, penetrates the first support bar and is fixedly connected with the eccentric wheel. The perforating machine for the manifold can achieve perforating without manually clamping the manifold by hand and can automatically clamp the manifold, thereby reducing the labor force, improving the working efficiency, lowering the operation risks and avoiding accidental injuries.