The invention discloses an automated medicine box packaging line. The automated medicine box packaging line comprises a flow-separation and channel-combination system (20), an intermediate conveying belt (5), a packaging machine (21) and a case sealer (22). The packaging machine (21) is composed of a box folding device (23), a stacking device (24), a conveying roller way (25), a case unpacker (26) and a labeling machine (27). The output end of the case unpacker (26) is in butt joint with one end of the conveying roller way (25), and the other end of the conveying roller way (25) is in butt joint with the inlet end of the case sealer (22). The labeling machine (27) is arranged beside the conveying roller way (25). A medicine box erecting device (28) and a medicine box appearance detection device (29) are sequentially arranged between the box folding device (23) and the intermediate conveying belt (5). The automated medicine box packaging line has the beneficial effects that the utilization rate of equipment is increased; small space is occupied; the automation degree is high; and medicine box packaging efficiency is greatly improved.