The invention discloses a wine bottle stopper capable of being opened or sealed quickly. The wine bottle stopper comprises a cylindrical plunger, a bracket, a sealing ring, a limiting pin, an expansion bag and a protection head, wherein the top of the plunger is connected with a knob; the bracket adapted to the plunger is arranged at the outer peripheral wall of the plunger; the sealing ring is arranged between the upper part of the plunger and the bracket; the limiting pin is arranged at the lower part of the plunger, and is matched with a groove in the bracket; the bracket is externally bonded with the expansion bag which expands when the plunger moves downwards and exerts a sealing function on a wine bottle mouth; and the protection head adapted to the bracket is arranged at the bottom end of the bracket, and is connected with the bottom of the plunger, so as to close the bracket to form a sealing cavity. The wine bottle stopper is simple in structure and convenient to use; a wine bottle can be quickly and reliably opened or sealed with only hands; the wine bottle stopper is applied to the wine bottle containing left wine; the sealability is good; the quality guarantee period of wine is prolonged; and the original flavor of the wine is reserved to the greatest extent and drinking experience of the wine is improved.