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发明授权
CN105968245B 一种粒径可调的具有核壳结构的含醛基纳米微球及其制备方法 有权

一种粒径可调的具有核壳结构的含醛基纳米微球及其制备方法
摘要：
本发明公开了一种粒径可调的具有核壳结构的含醛基纳米微球，该含醛基纳米微球的粒径为100～305nm，分散度为0.1～0.202，所述含醛基纳米微球的核单体为苯乙烯，壳单体为4‑乙烯基苯甲醛，或壳单体为苯乙烯和4‑乙烯基苯甲醛的混合单体，所述核单体和所述壳单体二者的质量份配比为4:1，该含醛基纳米微球粒径大小可调，分散度好。本发明还公开了一种含醛基纳米微球‑乳酸链球菌缀合物，采用上述含醛基纳米微球与乳酸链球菌制成，该含醛基纳米微球‑乳酸链球菌缀合物通过将含醛基纳米微球中的醛基与乳酸链球菌中的氨基相偶联，能避免乳酸链球菌的高温失活，增强其稳定性。
摘要（英）：

The invention discloses particle size-adjustable formyl group-containing nanoparticles with a core-shell structure. The particle size of the formyl group-containing nanoparticles is 100-305nm, and the dispersity is 0.1-0.202; the core monomer of the formyl group-containing nanoparticles is styrene, and the shell monomer is 4-vinyl benzaldehyde or a mixed monomer of styrene and 4-vinyl benzaldehyde; the mass part ratio of the core monomer to the shell monomer is 4:1; and the particle size of the formyl group-containing nanoparticles is adjustable while the dispersity is good. The invention also discloses a formyl group-containing nanoparticle-lactic streptococci conjugate which is prepared from the formyl group-containing nanoparticles and lactic streptococci; and by coupling the formyl group in the formyl group-containing nanoparticle-lactic streptococci conjugate with the amino in the lactic streptococci, the formyl group-containing nanoparticle-lactic streptococci conjugate can avoid high-temperature inactivation of the lactic streptococci and enhance the stability thereof.

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