The invention relates to a circuit breaker hybrid configuration method and device for a flexible DC power grid, and the device comprises transmitting end convertor stations, receiving end convertor stations, DC reactors, mechanical-type high-speed switches, and full-control type DC circuit breakers. The output end, located at a transmitting end convertor station circuit side, of each transmitting end convertor station is connected with a first branch circuit, formed by the series connection of the first and second mechanical-type high-speed switches, through the first DC reactor. A second branch circuit, formed through the series connection of the third and fourth mechanical-type high-speed switches and the first full-control type DC circuit breaker, is connected between the two first branch circuits in a parallel manner. The input end, located at a receiving end convertor station circuit side, of each receiving end convertor station is connected with one end of the second DC reactor, and a third branch circuit, formed by the series connection of the second full-control type DC circuit breaker and the fifth mechanical-type high-speed switch, is connected with the other end of the second DC reactor. A fourth branch circuit, which is formed by the series connection of the third and fourth full-control type DC circuit breakers, is connected between the two third branch circuits. The device can be widely used in a high-voltage flexible DC power transmission network.