The invention relates to a large-strain-performance pipeline steel plate of the X80 grade and a manufacturing method of a steel pipe. The steel plate used for the large-strain X80HD2 pipeline steel pipe comprises, by mass percent, 0.04%-0.07% of carbon, 0.15%-0.35% of silicon, 1.60%-1.70% of manganese, not larger than 0.008% of phosphorus, not larger than 0.003% of sulphur, 0.050%-0.065% of niobium, 0.012%-0.023% of titanium, 0.020%-0.030% of chromium, 0.20%-0.30% of copper, 0.20%-0.30% of nickel, 0.015%-0.025% of aluminum, not larger than 0.004% of nitrogen, not larger than 0.0005% of boron and the balance iron and inevitable impurities. The large-strain X80HD2 pipeline steel pipe has excellent transverse and longitudinal mechanical properties, and particularly the safety is ensured through the longitudinal property under the condition that bending deformation and strain of the steel pipe are caused by stratum changes under the geological conditions of permafrost zones, seismic zones and the like.