The present invention discloses an interference elimination method and device. The method comprises: converting an obtained time domain baseband signal to a frequency domain; performing channel estimation of the converted baseband signal on the frequency domain, and obtaining the frequency domain channel estimation value of the baseband signal; obtaining a reconstruction signal of the frequency domain according to the frequency domain signal estimation value and the frequency domain signal sent by a base station; converting the frequency domain reconstruction signal to the time domain, and determining an interference signal; and eliminating the interference signal in the time domain so as to solve the interference problem caused by uplink receiving signals and downlink sending signals have frequency offset in a TD-LTE co-frequency full-duplex system.