The invention discloses an automatic folding control system of an open carton. The automatic folding control system comprises a mold plate, a mold head, a first sensor, a second sensor, first drive devices, a second drive device and a control device. The mold plate is provided with a mold cavity. A first movable plate and four second movable plates are arranged in the mold cavity. The mold head comprises a first press plate matched with the first movable plate and second press plates matched with the second movable plates. The first drive devices are used for driving the first press plate to move vertically, and the second drive device is used for driving the second press plates to move vertically. The first sensor is used for detecting the distance between the upper plate faces of the second movable plates and the upper plate face of the mold plate, and the second sensor is used for detecting the distance between the upper plate face of the first movable plate and the upper plate faces of the second movable plates. The control device is used for acquiring detection data of the first sensor and the second sensor and meanwhile used for controlling the first drive devices and the second drive device to act. According to the automatic folding control system, the production efficiency of an enterprise is effectively improved, and the production cost of the enterprise is reduced.