The invention discloses an organic-inorganic compound chemical sand fixing agent. The organic-inorganic compound chemical sand fixing agent is prepared from, by weight, 4-6 parts of polyvinyl acetate, 1-3 parts of anionic polyacrylamide, 4-6 parts of silica sol, 1-3 parts of calcium chloride, 1-3 parts of sodium carbonate, 1-3 parts of styrene-acrylic emulsion and 15-81 parts of water. The invention further discloses a preparation method of the organic-inorganic compound chemical sand fixing agent. The organic-inorganic compound chemical sand fixing agent has a good sand fixing effect, when the organic-inorganic compound chemical sand fixing agent is sprayed to the surface of sand, a net coating film can be formed easily to wrap the sand grains, and a stable and solid sand crust is formed. The formed sand crust is not likely to be broken, has certain toughness and facilitates water seepage, stability can be kept after the sand crust is in contact with water, and the sand fixing effect is enhanced. The preparation method of the organic-inorganic compound chemical sand fixing agent is simple, controllability is high, the preparation conditions are mild, the preparation time is short, the yield is high, the raw materials are easy to obtain, few raw materials are adopted, cost is reduced, and the pollution of the organic-inorganic compound chemical sand fixing agent to the environment is reduced.