The invention relates to a multi-layer glass energy-saving curtain wall which comprises a curtain wall keel, glass panels arranged on the curtain wall keel and pressing plates used for pressing the glass panels to the curtain wall keel. At least two layers of glass panels are arranged. A heat-isolation layer is arranged between the glass panels on the two outermost layers of a wall body. Compared with the prior art, the glass panels are designed to be multiple layers, glass texture can be improved through the light refraction effect of multi-layer glass, and the heat-isolation layer is arranged between the two outermost glass panels. Compared with other modes, the heat-isolation effect is better, and the energy-saving effect is obvious.