A device for determination of the dust production amount of drug granules comprises a main body, a rotary motor (3) and a rotary bottle (13); the rotary motor (3) is mounted on the main body; the main body comprises a machine head (1), a stand column (16) and a base (8); a dust sampler (6) is fixed on the base (8); one end of a dust sucking pipe (4) is connected with a gas inlet (5) of the dust sampler (6), the other end of the dust sucking pipe (4) is mounted into the rotary motor (3), a sealing rubber ring (15) is used for fixing the dust sucking pipe (4) tightly, then a filter membrane (12) after being weighed is inserted into one head of the dust sucking pipe, a glass joint (14) is mounted, and then a screw cap (11) is used for fixing the glass joint tightly. The device can detect the dust amount of drug granule samples generated due to friction and collision in a state of motion while general dust testers cannot detect the dust amount. Therefore, development and production of the drug granules can be well guided.