The invention relates to a non-directional screening method for azopigment in chilli sauce, and belongs to the technical field of food detection. The method comprises the steps that detection is conducted by adopting a liquid chromatography-quadrupole mass spectrometer with an electrospray ionization source, precursor ion scanning detection is conducted by taking m/z156 as daughter ions, and azopigment screening is conducted through the mass-to-charge ratio of precursor ions corresponding to chromatographic peaks in a mass chromatogram; if a total ion chromatogram containing the daughter ions 156 is obtained, it shows that a test sample contains the azopigment; the mass numbers of parent ions corresponding to the chromatographic peaks in the total ion chromatogram are checked one by one, and then forbidden or restricted pigments contained in the sample can be determined by contrasting a possible azopigment list. According to the method, when detection is conducted, no standard substance is needed for contrasting, a professional screening database does not need to be established through the standard substances, therefore, the detection cost is significantly reduced, and detection is not limited by the conditions that the standard substances are lacked, and no professional database exists; sample pretreatment only needs 20 min, instrumental analysis needs 15 min, and the single sample non-directional screening whole process only needs 35 min.