The invention relates to an optimized assessment method and device for management and control of regional flexible loads, and belongs to the technical field of regional load control. Assessment indexes of flexible loads are determined, and an index initial matrix is established; the established index initial matrix is standardized and weighted, and a positive ideal solution and a negative ideal solution of the processed matrix are calculated; and according to distances from each assessment index of the flexible load to the positive ideal solution and the negative ideal solution, the approaching degrees relative to the negative ideal solution is calculated, the approaching degrees relative to the negative ideal solution of the flexible loads are ordered, and basis is provided for making a load scheduling plan of a power company. The assessment method can be used to assess the level and effect, in response to power management and control, of the flexible loads in the region, reference is provided for making the flexible load scheduling plan of the power company, the degree of participating scheduling of the flexible loads is improved, and the power company can make priority scheduling according to the optimized assessment method of the invention so that regional power grid achieves highest economical and reliable performances.