The invention relates to a regional multi-distributed-power-supply autonomous power generation control method and a device. The method comprises the steps as follows: for a regional distributed power supply system, receiving a planned active power value scheduled and issued by a distribution network, comparing the planned active power value with the actual total output of the distributed power supplies in a current region, and calculating the target generated output of each distributed power supply i; if the actual total output of the distributed power supplies in the current region is smaller than the planned active power, increasing the active power output of the regional distributed power supply system; and if the actual total output of the distributed power supplies in the current region is greater than the planned active power, reducing the active power output of the regional distributed power supply system. The influence of high-permeability connection of regional distributed power supplies to the grid can be reduced, the difficulty of multi-distributed-power-supply scheduling control by a distribution network can be reduced greatly, and the ability of the grid to consume distributed power supplies and the operation reliability of the grid are improved.