The invention provides a full-digital control module for a programmable DC power supply. The full-digital control module comprises a sampling circuit, an FPGA processing circuit, a switch power conversion circuit, the sampling circuit, an AD circuit and a drive circuit, wherein output voltage and current are processed by the sampling circuit and then are directly conveyed into the AD circuit to be converted into a sampling signal of digital quantity; the sampling signal is compared with a set digital reference value in the FPGA processing circuit to obtain an error signal of the digital quantity; the error signal is calculated through the FPGA processing circuit to obtain a digital control signal with adjustable frequency and duty ratio; the control signal is buffered and driven through the drive circuit; on or off of a switch tube in the switch power conversion circuit is controlled; and closed loop control of the voltage and the current is finished. According to the full-digital control module for the programmable DC power supply, the loop compensation complexity can be effectively reduced; an automatic compensation control function under various input and load states is achieved; and the problem of reduction of the power conversion stability under a fast adjustment state is solved.