The invention provides an antenna device and a mobile terminal. The antenna device comprises an antenna, a front end module, a first power amplifier, a first filter and an anti-interference module; the antenna is connected with the front end module, the front-end module and the first power amplifier are connected to form a first access, the front-end module, the first filter and the first power amplifier are connected in sequence to form a second access, and the anti-interference module is connected with the first power amplifier; and the anti-interference module is used for acquiring a working frequency band of a carrier in real time, controlling the first power amplifier to close the first access and open the second access when the working frequency band of the carrier satisfies a preset condition, and controlling the first power amplifier to open the first access and close the second access when the working frequency band of the carrier does not satisfy the preset condition. The antenna device provided by the invention has the beneficial effects of reducing the harmonic interference during carrier aggregation.