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发明公开
CN106032534A 一种与人非小细胞肺癌细胞特异结合的核糖核酸适配体及其筛选方法 有权 转让

一种与人非小细胞肺癌细胞特异结合的核糖核酸适配体及其筛选方法
摘要：
本发明涉及一种与人非小细胞肺癌细胞特异结合的核糖核酸适配体(RNA aptamer)及其筛选方法。本发明人基于活体内in vivo-SELEX筛选技术，获得了一条可以与人非小细胞肺癌细胞特异性结合的核糖核酸适配体(RNA aptamer)。该核糖核酸适配体可应用于与肺癌化疗药物、siRNA等结合，构成靶向性药物，以实现肺癌的靶向治疗。该核糖核酸适配体与荧光染料等结合，可以制备人非小细胞肺癌的诊断试剂。
摘要（英）：

The invention relates to a ribonucleic acid (RNA) aptamer capable of specifically being combined with human non-small cell lung cancer cells and a screening method thereof. Based on an in-vivo-SELEX screening technology, an RNA aptamer that can be specifically combined with human non-small cell lung cancer cells is obtained. The RNA aptamer can be combined with chemotherapeutic drugs and siRNA to form targeting drugs so as to realize the targeted therapy of lung cancer. Moreover, the RNA aptamer can be combined with a fluorescent dye to prepare a reagent for diagnosing human non-small cell lung cancer.

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