The invention provides potassium citrate and sodium citrate tablets and a preparation method of the potassium citrate and sodium citrate tablets. According to the potassium citrate and sodium citrate tablets and the preparation method, potassium citrate and sodium citrate are smashed, the obtained powder is subjected to vacuum drying till the water content is smaller than 2%, then the obtained dry powder is charged, and meanwhile, the environment humidity during the preparation process is controlled, so that the water content of the prepared tablets is smaller than 3%; a high-viscosity adhesive is selected for carrying out pelleting, so that the dissolving out of potassium citrate and sodium citrate is retarded, and the absorption of the medicine is improved. The potassium citrate and sodium citrate tablets have good dissolution and stability, and bring good curative effects and safety to the clinic and patients.