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发明公开
CN106046076A 一种从香茶菜属植物同时制备细花线纹香茶菜苷A和咖啡酸乙酯的方法 有权

一种从香茶菜属植物同时制备细花线纹香茶菜苷A和咖啡酸乙酯的方法
摘要：
本发明提供一种从香茶菜属植物同时制备细花线纹香茶菜苷A和咖啡酸乙酯的方法，所述香茶菜属植物是指除了植物溪黄草Isodon serra(Maxim.)Kudo外的该属其它植物，所述方法包括如下步骤：I.药材的提取：药材用40％～95％的乙醇溶液提取；II.分离：药材提取液先后经过大孔树脂柱吸附洗脱、有机溶剂萃取等步骤得到混合物粗品；III.精制：混合物粗品经Sephadex LH‑20柱层析、结晶和重结晶，得到高纯度的细花线纹香茶菜苷A和咖啡酸乙酯。利用本发明的方法，可以为药材溪黄草的质量控制提供特征的对照品，从而为相关药品的质量控制提供保证。
摘要（英）：

The invention provides a method for simultaneously preparing Isodon lophanthoides var. graciliflora glycoside A and ethyl caffeate from Rabdosia plants. The Rabdosia plants are all other plants except Isodon serra (Maxim.)Kudo. The method comprises the following steps: I. medicinal material extraction: extracting the medicinal material with a 40-95% ethanol solution; II. separation: sequentially carrying out macroporous resin column adsorption elution, organic solvent extraction and the like on the medicinal material extracting solution to obtain a mixture crude product; and III. refinement: carrying out Sephadex LH-20 column chromatography, crystallization and recrystallization on the mixture crude product to obtain the high-purity Isodon lophanthoides var. graciliflora glycoside A and ethyl caffeate. The method can provide characteristic reference substances for quality control on the medicinal material rabdosia lophanthide, thereby providing a guarantee for quality control on related medicines.

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