The invention requests to protect an interference elimination and antenna optimization method in a multi-cell large-scale MIMO system, and provides an interference alignment method combining joint spatial division and multiplexing with antenna selection. A user side design a joint receiving filter matrix, compresses an interference space and overcomes the rapid increasing of the quantity of user terminal antennas along with the increasing of a user quantity; a base station side adopts an antenna selection algorithm with low complexity, and selects an appropriate channel vector, so that the quantity of main characteristic values of a channel covariance matrix and the quantity of the selected antennas meet a certain relationship, and thus the combination of interference alignment and joint spatial division and multiplexing is well achieved. Theoretical analysis and estimation results indicate that by using the interference alignment method combining joint spatial division and multiplexing with antenna selection provided by the invention, the system interference can be eliminated, and when the user quantity is large, the quantity of the antennas required by the base station side and the user side is reduced.