The invention discloses a substation inspection intelligent guide system based on GPS positioning, which comprises a CPU. The CPU is connected with a GPS module, a keyboard, a battery module, a memory and a speech circuit via a wire respectively; the GPS module is connected with an antenna via a wire; the speech circuit is connected with a loudspeaker device via a wire; and the loudspeaker device comprises a shell, a loudspeaker, a nut, a screw rod, a sliding rail, a battery, a wireless signal transmitting device, a pulse generating device and a stepping motor. The invention aims at providing an intelligent guide system for power system substation inspection, thereby solving defects of the above conventional inspection. The battery is adopted for power supply, positioning is realized based on the GPS module, the speech for the device inspection method and safety precautions are automatically played through recognizing GPS coordinates of the substation device, and according to the substation inspection path, a person is guided to perform inspection on devices one by one.