The invention discloses a vacuumizing method for pipeline transport by applying vacuum pump exhaust and vehicle operating exhaust in stages. According to the vacuumizing method, a vacuum pump which is arranged along a pipeline and a vehicle which is arranged in the pipeline are adopted to vacuumize the pipeline. The process of exhausting air in the pipeline is firstly divided into five stages according to the gas pressure in the pipeline, namely, 1-(0.3-0.02) atm, (0.3-0.02)-0.01 atm, 0.01-0.001 atm, 0.001-0.0001 atm and 0.0001-0.00001 atm. In the first stage, the vacuum pump arranged along the pipeline is adopted for exhaust. In the exhaust processes of the second stage, the third stage, the fourth stage and the fifth stage, vehicle operating exhaust is adopted. The vacuumizing method for pipeline transport by applying vacuum pump exhaust and vehicle operating exhaust in stages improves the exhaust efficiency and reduces operating cost.