利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN106083703A 一种新型手性开链吡哆胺催化剂及其合成方法与应用 无效 - 撤回

一种新型手性开链吡哆胺催化剂及其合成方法与应用
摘要：
本发明涉及一种新型手性开链吡哆胺催化剂及其合成方法与应用，所述的吡哆胺催化剂的结构通式如下：其中，R1、R2、R3和R4分别为氢、C1‑24的烃基、含取代基的C1‑24烃基、或卤素中的一种，所述的C1‑24烃基上的取代基为O‑Rw、S‑Rw′或卤素，其中，Rx、Rx′、Ry、Ry＇、Ry″、Rz、Rz＇、Rw和Rw′分别为氢、甲基、乙基、正丙基、异丙基、正丁基、叔丁基、环戊基、环己基、环庚基、苯基、苄基、(1‑苯基)乙基、1‑萘基、2‑萘基或卤素中的一种。与现有技术相比，本发明的吡哆胺类催化剂可以实现手性氨基酸的快速高效合成，制备原料易得，反应条件温和，成本低，用于转氨化反应时，条件温和，反应稳定等。
摘要（英）：

The invention relates to a novel chiral open-chain pyridoxamine catalyst and a synthesis method and application thereof. The structural general formula of the pyridoxamine catalyst is shown in the specification, wherein R1, R2, R3 and R4 are one of hydrogen, C1-24 alkyl, C1-24 alkyl containing substituent groups, substances shown in the specification and halogen, the substituent groups on C1-24 alkyl are a substance shown in the specification or a substance shown in the specification or a substance shown in the specification or O-Rw or S-Rw' or halogen, and Rx, Rx', Ry, Ry', Ry'', Rz, Rz', Rw and Rw' are one of hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, tertiary butyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl, benzyl, (1-phenyl)ethyl, 1-naphthyl, 2-naphthyl and halogen. Compared with the prior art, the pyridoxamine catalyst can achieve rapid and efficient synthesis of chiral amino acid, the preparation raw materials are easy to obtain, reaction conditions are mild, cost is low, and when the novel chiral open-chain pyridoxamine catalyst is used for a transamination reaction, the conditions are mild, and the reaction is stable.

0/0