The invention discloses thick automobile inner chamber leather with pressure resistance and friction-resistant color fastness. The thick automobile inner chamber comprises a base cloth layer and a surface layer coating one surface of the base cloth layer, wherein the surface layer is a four-layer structure and comprises a water-base PU bottom layer, a water-base PU foamed layer, a water-base PU reinforcing layer and a water-base PU surface layer which are sequentially connected. According to the thick automobile inner chamber leather, the base cloth layer has the effects of resisting bacteria and ultraviolet light and retarding combustion; the surface layer is a four-layer structure and has strong leather sensation, and the four layers are made of a water-base polyurethane emulsion, so that the environmental protection property is good, the strength is high, and the water repellency and the gas permeability are strong; the PU foamed layer is of a hollow formed structure and is light, so that the automobile inner chamber leather is endowed with relatively rebound resilience and compression strength; nano-TiO2 powder, nano-ZnO powder and polyol fatty acid ester are further added into the water-base PU surface layer, so that the automobile inner chamber leather has relatively strong light aging resistance and static electricity resistance; by utilizing a Dow Corning DC-57 organosilicon polyether copolymer, the automobile inner chamber leather is smooth and wearable and has strong friction-resistant color fastness.