The invention discloses a hybrid-fiber three-dimensional-braided thermosetting-resin-matrix-composite-material oil-pumping-rod centralizer. The hybrid-fiber three-dimensional-braided thermosetting-resin-matrix-composite-material oil-pumping-rod centralizer comprises an oil-pumping-rod centralizer body, anti-wear edges arranged on the outer surface of the oil-pumping-rod centralizer body and wear-resistant layers with which the surfaces of the anti-wear edges are coated. The oil-pumping-rod centralizer body, the anti-wear edges and the wear-resistant layers are formed in the mode that fiber three-dimensional braided fabrics and modified thermosetting resin are impregnated; the oil-pumping-rod centralizer body is of an oppositely-inserted two-half structure, a plurality of metal protruding balls are embedded into the oppositely-jointed sliding groove position of a single structure unit, metal buckles are embedded into the oppositely-jointed end, and the oil-pumping-rod centralizer body and the buckles are fixedly and integrally designed through the sliding grooves; an oil-pumping-rod clamping cavity is formed in the inner side of the oil-pumping-rod centralizer body, and is internally provided with a zigzag friction strip and sphere glue storing grooves. By means of the hybrid-fiber three-dimensional-braided thermosetting-resin-matrix-composite-material oil-pumping-rod centralizer, the interfacial defects of the centralizer body structure is effectively overcome, the whole mechanical strength, the rigidity, the wear resistance and the corrosion resistance of the centralizer are effectively improved, and the service life of the centralizer is effectively prolonged.