The invention discloses a smart control method for a transformer cooler. The method includes the steps of obtaining the real-time temperature T of a winding of a transformer, setting the constant operation temperature value of the transformer, a control unit determining the cooler control strategy according to the real-time temperature T and the temperature changing rate DT/Dt, and outputting a control signal to the transformer cooler according to the strategy. The working of the transformer cooler can be controlled timely and effectively to lower the temperature of a transformer, prevent the transformer from being damaged, and prolong the service lifetime of the transformer. Switching of the cooler set of a cooler can be conducted to prevent frequent switching of cooler sets and prevent switches from being damaged. Stable operation of an entire cooler is ensured, and the transformer operates more stable.