The invention discloses a driving method of a display panel, a multiplexer, and the display panel. The driving method comprises steps that every N frames of a display image are used to form a driving period, and every two rows of pixel units of every frame of the display image are used to form a sub-driving period. Display colors of a last-charged sub-pixel of a former row of pixel units, the last-charged sub-pixel of the next row of pixel units, the last-charged sub-pixel of the former sub-driving period, and the first-charged sub-pixel of the next sub-driving period are the same. The sub-pixel charging clock signal of the last-charged sub-pixel of the former row of pixel units can last till the completion of the charging of the first-charged sub-pixel of the next row of pixel units, and then high-level low-level switching is carried out. The sub-pixel charging clock signal of the last-charged sub-pixel of the former sub-driving period can last till the completion of the charging of the first-charged sub-pixel of the next sub-driving period, and then the high-level low-level switching is carried out. The power consumption of the display panel is reduced.