The invention discloses a comprehensive anti-galloping method of an extra-high voltage vertically arranged power transmission line. The method comprises the following steps of (A) determining hanging point positions of phase-to-phase spacers of the power transmission line according to the span of the power transmission line and installing the phase-to-phase spacers according to the hanging point positions; (B) determining the hanging point positions of phase-to-ground spacers on a lower phase conductor according to the span of the power transmission line; (C) determining the position of a ground anchor according to the predominant wind direction of an area in which the power transmission line is located and making the phase-to-ground spacers on the lower phase conductor located in a vertical plane after connecting the phase-to-ground spacers and an inverse predominant wind direction of the ground anchor; and (D) arranging the phase-to-ground spacers on the hanging points of the phase-to-ground spacers on the lower phase conductor, adjusting the line drawing lengths of the lower ends of the phase-to-ground spacers and keeping the pre-tightening force of the phase-to-ground spacers at 3-5kN at 0 DEG C. By combination of the phase-to-phase spacers and the phase-to-ground spacers, a good anti-galloping effect can be developed when the power transmission line gallops; meanwhile, the influence of an anti-galloping device on tension of the power transmission line is effectively reduced; and safe operation of the line is ensured.