Embodiments of the invention are generally directed to compositions comprising glucose oxidase containing botanical extracts, and in particular extracts of Fabiana imbricata. The compositions are useful for reducing pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3'-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a cosmetically acceptable vehicle.