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发明公开
CN106119396A 一种与桥本甲状腺炎辅助诊断相关的血浆miRNA标志物及其应用 有权

一种与桥本甲状腺炎辅助诊断相关的血浆miRNA标志物及其应用
摘要：
本发明公开一种与桥本甲状腺炎辅助诊断相关的血浆miRNA标志物及其应用，该标志物为miR‑205，miR‑20a‑3p，miR‑375，miR‑296，miR‑451和miR‑500a中的一种或多种。血浆miRNA作为新型的生物标志物，具有稳定性好、微创易获取，灵敏性和特异性高的特点。这类分子标志物的开发利用将为包括桥本甲状腺炎在内的各种疾病的诊断以及进一步治疗提供新的方向。本研究将更有针对性的得出具有临床诊断潜能的桥本甲状腺炎血浆miRNA标记物。研究证实了这组miRNA作为诊断桥本甲状腺炎的无创标记物的可靠性以及可重复性。
摘要（英）：

The invention discloses a plasma miRNA marker related to hashimoto thyroiditis assisted diagnosis and application of the plasma miRNA marker. The marker is one or more of miR-205, miR-20a-3p, miR-375, miR-296, miR-451 and miR-500a. The plasma miRNA marker serving as a novel biological marker is good in stability, minimally invasive, easy to obtain and high in sensitivity and specificity. The development and utilization of the molecular marker can provide a new direction for the diagnosis and further treatment of various diseases including the hashimoto thyroiditis. The hashimoto thyroiditis plasma miRNA marker with clinical diagnosis potential can be obtained in a targeted manner by researches. The reliability and reproducibility of the group of miRNA serving as the non-invasive marker of the hashimoto thyroiditis are proved by researches.

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