The invention discloses a radio frequency interference device, comprising a machine body, a power supply module and a power amplifier. A control module and a display module are arranged on the outer wall of the machine body. The output end of the power supply module is electrically connected with an input end of a radio transmission module. The power amplifier is composed of a low frequency amplifier, an intermediate amplifier and a high frequency amplifier. The output ends of the low frequency amplifier, the intermediate amplifier and the high frequency amplifier are electrically connected with the input end of the control module. The output end of the control module is electrically connected with an input end of a processor. The output end of the processor is electrically connected with the input end of the display module. According to the radio frequency interference device, the structure design is simple, the use operation is convenient, through adoption of an electronic digital modulation scrambling interference mode, the interference effect is more reliable, a bomb explosion due to wireless signal remote control and transmission can be effectively avoided, and people and articles are prevented from suffering from a damage and loss.